The human meiotic recombination 11 homolog (MRE11A) gene encodes a protein with a central role in DNA double-stranded repair. Several proteins form a complex with MRE11A, such as NBN and RAD50. We used MRE11A as a bait protein in affinity purification-mass spectrometry (AP-MS) experiments as a proof of principle for using endogenously-epitope tagged cell lines for AP-MS.

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  • Taxonomy=Homo sapiens


Song et al, Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry. Journal Proteome Research, 2012 (PubMed).